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Senior Scientific Manager, Assay Development and Screening Core

About Achaogen :

Our vision is to change the way people think about the discovery and development of new drugs for the treatment of serious multi-drug-resistant infections. According to the Centers for Disease Control and Prevention (CDC), at least 2 million people become infected with antibiotic-resistant bacteria each year in the United States, and 23,000 people die annually because of these infections. By 2050 antimicrobial resistance is projected to result in ~10 million deaths per year. Furthermore, the need for new antibiotics to treat carbapenem-resistant-Enterobacteriaceae (CRE) is particularly acute, and in 2013, the CDC labeled CRE as “nightmare bacteria” and indicated that CRE pose a public health threat requiring “urgent and aggressive action.”

Achaogen is developing plazomicin, our lead product candidate, for the treatment of serious bacterial infections due to MDR Enterobacteriaceae, including CRE. Our second product candidate is C-Scape, an orally-administered beta-lactam/beta-lactamase inhibitor combination. 

In addition to our deep expertise in infectious diseases and antibiotic drug discovery, we have established a state of the art antibody discovery platform that enables us to opportunistically expand outside of infectious diseases and tackle additional therapeutic areas with tremendous patient need. Having both small molecule and antibody drug discovery development capabilities gives us the opportunity to tackle the most compelling targets with the most appropriate drug modality.

Intrinsic to our five key core values of integrity, accountability, transparency, scientific rigor, and drive, Achaogen is committed to addressing such public health crisis affecting millions globally. With a focused strategy that leverages the passion and talent of our scientists, we have established specialized research and development capabilities in antimicrobial research and drug discovery.

At a Glance

We seek an inspired leader to chart the future of the Assay Development and Screening (ADSC) group at Achaogen, a multidisciplinary team that touches all aspects of our research organization.

About You - What You’ll Do

In collaboration with all research departments, develop a 3-year roadmap of assays, workflows and infrastructure to support the growing discovery pipeline needs and to ensure that the most promising drugs transition from research to early development

  • Effectively communicate ADSC vision, goals and objectives to the team members and the broader research management team
  • Invest in the growth and development of the team by engaging in regular professional development discussions and introducing appropriate opportunities
  • Identify novel methodologies and emerging technologies to improve the way we identify and optimize drugs
  • Lead and work closely with cross-functional discovery teams to achieve project goals
  • Establish the most appropriate assays for screening in vitro and in vivo biological targets and oversee screening operations, including scheduling, assay performance and data flow. 

 

About You - What You’ll Need

  • Experience in and a passion for evolving the way we identify new drugs
  • Exceptional organizational skills
  • Ability to succinctly communicate complicated scientific problems
  • Proactively seek out opportunities for the team to solve
  • Flexible and versatile
  • Motivate, inspire and guide employees to do their best
  • Attract and hire top talent
  • Working knowledge of state of the art assay technologies to enable drug discovery
  • Ability to work cross-functionally to engage stakeholders in a broader vision
  • BS/MS in a relevant scientific discipline
  • Minimum 5 years post graduate research experience in an industry setting
     

About the Team

  • Scientifically rigorous
  • Fun to work with
  • Gets stuff done
  • Flexible to the dynamic needs of the organization

 

 

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