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Senior Scientist, Process Chemistry

Position Summary:

Achaogen is seeking a talented and innovative individual to join our process chemistry department as Senior Scientist II, Process Chemistry.  The successful candidate will be responsible for various aspects of CMC including overseeing the manufacture of API for clinical supplies and managing external contract manufacturing organizations. This function includes the design, development, optimization, and scale-up of chemical processes to support the company’s development and commercial goals. Strong skills in synthetic methodology, route scouting, and analytical methods are required to support this role. Must work cross functionally in a dynamic organization that is planning for the launch of its first commercial product.


Essential Functions:

  • Provides leadership and technical oversight for development of drug substance, intermediates, and regulatory starting materials.
  • Oversee the design, development, and scale-up of chemical processes for the preparation of the company’s drug candidates ensuring cost effectiveness, minimal environmental impact, and manufacturing safety.
  • Work closely with Regulatory Affairs supporting IND, CTA, NDA, and MAA submissions.
  • Laboratory based process and synthetic chemistry methods.
  • Problem solving ability for data evaluation and interpretation.
  • Contribute as a participating CMC member and execute the company’s strategy into functional plans, including processes for the initial, interim, and ultimate production of drug substance for clinical and commercial operations. 


Preferred Experience:

  • 5-7 years of relevant process development experience.
  • Recent laboratory experience and understanding of process design and definition through statistical methods.
  • Demonstrated scientific excellence, with expert knowledge of scientific principals and concepts.
  • Experience managing external contract manufacturing organizations.
  • Experience with cGMP manufacturing of active pharmaceutical ingredients.
  • Basic knowledge of Quality and Regulatory functions.
  • A track record of innovation, self-starting and success managing multi-disciplinary teams and projects under defined timelines.


Preferred Education:

  • Ph.D. in Chemistry, Chemical Engineering or Pharmaceutics, with 5-7 years of experience or a BS/MS with >10 years of experience in a process synthetic chemistry position.  Demonstrated technical proficiency with chemical reactions, isolations, separations and purifications.


Preferred Additional Skills:

  • Strong organizational and management skills, and ability to effectively manage multiple priorities and projects.
  • Independent, innovative, and creative thinker with outstanding written and verbal communication skills.
  • Proven ability to positively impact company culture.
  • Demonstrated flexibility in fast paced environment.
  • Committed to the values of integrity, accountability, transparency, scientific rigor and drive.
  • Current US work authorization required.



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