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Scientist I/II, Clinical Pharmacology

Position Summary:

Achaogen is a clinical-stage biopharmaceutical company passionately committed to the discovery, development, and commercialization of innovative antibacterials to treat multi-drug resistant, Gram-negative infections. In light of recent positive Phase 3 data for our NDA-candidate with breakthrough therapy designation, plazomicin, and a growing pipeline that includes two small molecules in early development and multiple large and small molecule discovery programs, we are looking for an accomplished scientist to join our growing clinical pharmacology group.

We seek a highly motivated and driven scientist to contribute to Achaogen’s clinical and early development programs, including innovative first-in-human studies, PK/PD analyses (nonclinical and clinical), and dose selection. If you are passionate about science, like working as part of a team, are looking to grow in your career, and are committed to performing rigorous experiments that inform drug development, then this is the place for you!

Essential Functions:

  • Oversee scientific and technical aspects of clinical pharmacology studies from conception through final report, including first-in-human, mass balance, drug-drug interactions, organ impairment, and pediatric and other special population studies.
  • Collaborate with microbiology and in vivo pharmacology functions to develop and evaluate PK/PD models that inform clinical dose selection.
  • Perform PK data analysis and interpretation, including noncompartmental analysis (NCA); assist in the design and interpretation of population PK and PK/PD models.
  • Contribute to regulatory submissions, including INDs, IBs, NDAs, and MAAs.
  • Identify and manage external vendors and consultants.
  • Work closely with clinicians, microbiologists, biostatisticians, regulatory affairs, and clinical operations to ensure that protocols capture critical PK and PD endpoints.
  • Provide clinical pharmacology expertise on cross-functional teams; identify and communicate potential project hurdles, suggest solutions, and leverage the clinical pharmacology leadership to establish priorities and contingency plans.
  • Present operational plans, scientific data and strategy to internal and external audiences, including regulators, key opinion leaders, partners, and executives.
  • Produce high quality clinical pharmacology publications that present Achaogen data, and represent the company at scientific and community meetings.

Essential Experience:

  • 3+ years of relevant industry experience in clinical pharmacology, pharmacometrics, DMPK or related discipline(s).
  • In-depth knowledge of related disciplines (e.g., DMPK, chemistry, infectious disease, translational medicine, biostatistics, toxicology, regulatory) in the drug development process.
  • Experience with PK and PK/PD data analysis, interpretation, and reporting, including hands-on experience with modeling software (e.g. Phoenix, etc).
  • Record of scientific excellence, including publications in top tier journals.
  • Travel required (approximately 5% - 10% of time).


  • PhD (or PharmD with relevant post-doctoral training) in clinical pharmacology, pharmacometrics, or related field.

Preferred Additional Skills:

  • Working knowledge of modeling software (Simcyp, GastroPlus, NONMEM, SPLUS, R, etc.).
  • Experience with PK/PD for antibiotics.
  • Motivated and passionate about making a difference for unmet medical needs.
  • Strong oral and written communication skills and business partnering ability.
  • Strong interpersonal skills and ability to work with others in a positive, collaborative manner, inspiring trust and confidence with colleagues.
  • Committed to values of integrity, accountability, transparency, scientific rigor and drive.
  • Current US work authorization required.
  • Ability to travel internationally.



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