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Scientist/Sr. Scientist Computational Chemistry

Achaogen is seeking a Computational Chemist to join our multidisciplinary research team. The successful candidate will support small and large molecule project teams through target identification, hit discovery, and lead optimization. It is expected that the successful candidate will have a proven track record of collaborative teamwork to solve challenging scientific issues. A qualified candidate will be entrepreneurial, detail-oriented, well-networked, and be able to flexibly apply computational methods to a wide range of scientific problem solving.

For small molecule drug discovery, collaborative work with medicinal chemists and project teams to identify novel chemistry starting points and design compounds with improved potency, selectivity, functional activity and/or ADME properties will be a core work function. In addition, the work will include coaching scientists and non-scientists to analyze, interpret, and visualize biological data, and communication these results. Working with the head of chemistry the role holder will build an in-house and networked computational chemistry infrastructure being solely accountable for devising, championing or developing state of the art computational chemistry techniques that solve key problems for project and chemistry teams.


In addition, Achaogen also undertakes large molecule drug discovery and the candidate will be expected to contribute to ongoing research efforts in collaboration with internal scientists.


Additionally, the role holder may take on the chemistry and / or project leadership of drug discovery teams.



  • A Ph.D. (or equivalent) in Computational Chemistry, Organic Chemistry or a related discipline
  • 10 years of pharmaceutical or biotech experience demonstrating a strong understanding of the impact of computational techniques at all stages of drug discovery
  • Expert knowledge of the state-of-the-art for computational chemistry and the application of collaboration, both academic and industrial
  • Experience with commercial molecular modeling and data mining software


Preferred Requirements

  • Expertise with a wide array of computational methods
  • Preferably including structure and ligand-based virtual screening, scaffold morphing, programming, statistics, data analysis, QSAR derivation and application, and ADME modeling
  • Expert understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
  • A strong record of delivering portfolio success and driving projects through to the identification of high quality small-molecule drug candidates
  • Excellent awareness of current developments in computational chemistry and ability to identify opportunities to advance the science in this field


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