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Senior Scientist, In Vivo Pharmacology

Position Summary:

Achaogen is a clinical-stage biopharmaceutical company passionately committed to the discovery, development, and commercialization of innovative antibacterials to treat multi-drug resistant, Gram-negative infections. In light of recent positive Phase 3 data for our NDA-candidate, plazomicin, and a growing pipeline that includes two small molecules in early development and multiple large and small molecule discovery programs, we are looking for an accomplished in vivo pharmacologist to build out that function within our translational medicine group.


We seek a highly motivated and driven scientist with proven leadership abilities. This position will provide an exciting opportunity to build an in vivo pharmacology function focused on conducting non-clinical in vivo studies to support programs across research and development. If you are passionate about science, are strategically agile, like working in a team, are looking to grow in your career and are committed to performing rigorous experiments that inform drug development, then this is the place for you!



  • Lead the translational medicine group, with accountability for all scientific, operational, compliance and IACUC-related activities in Achaogen’s vivarium (husbandry, cage supplies, weekend checks are managed separately).
  • Provide in vivo pharmacology expertise to project teams during the discovery and development phases of biologics and small molecule drug discovery programs for infectious diseases, pain, vascular biology, and other therapeutic areas of high unmet need.
  • Develop innovative preclinical in vivo models that enable interrogation of mechanisms of action, diagnostic hypotheses, and mechanisms of resistance.
  • In collaboration with scientists from other functional areas: design, perform, analyze and interpret in vivo studies that may include: antibody immunization, tolerability/toxicology, DMPK and pharmacology/efficacy and biomarker discovery/validation studies.
  • Grow and manage a team of in vivo research associates and technicians.
  • Author reports and documents to support regulatory filings, patent applications and peer-reviewed manuscripts.


Essential Experience:

  • 5 or more years of relevant industry experience in conducting non-clinical in vivo studies, including experience with small molecules and antibody therapeutics.
  • 2 or more years of management experience.
  • Record of scientific excellence, including publications in top tier journals.


Preferred Experience:

  • Experience in preparing regulatory submissions (e.g. IND).
  • Experience with animal models of toxicology, pain, vascular dysfunction or infectious disease.



  • PhD in a relevant scientific discipline.


Preferred Additional Skills:

  • Motivated and passionate about making a difference for unmet medical needs.
  • Strong oral and written communication skills and business partnering ability.
  • Strong interpersonal skills and ability to work with others in a positive, collaborative manner, inspiring trust and confidence with colleagues.
  • Willingness to be a “hands-on, roll-up-your sleeves” leader.
  • Committed to values of integrity, accountability, transparency, scientific rigor and drive.
  • Current US work authorization required.
  • Ability to travel domestically.
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