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Postdoctoral Researcher, Synthetic Chemistry

Position Summary:

The aminoglycoside class antibiotic drugs present significant intellectual and practical challenges especially with respect to their preparation which limits our ability to identify, characterize, and optimize new candidates.  To address this, we aim to develop a wide-range of novel synthetic chemistry routes and procedures to aid in the diverse production of novel aminoglycosides both at milligram and multigram scales.

We are seeking a highly motivated Postdoctoral Research Fellow to join our Medicinal Chemistry group and engage in novel synthetic chemistry research. The proposed research project will involve the elucidation of novel synthetic chemistry, novel synthetic routes, and the development of innovative chemical systems such as flow chemistry, to enable access to novel aminoglycosides.

The Achaogen postdoctoral program is an immersive three-year opportunity designed to enable highly independent and motivated scientists to perform impactful basic or translational research in a biotech-industry setting.  Fellows will be paired with an internal scientific mentor and integrate into in a highly interdisciplinary environment, surrounded by high-caliber researchers with diverse scientific backgrounds.  We strive to empower Achaogen postdocs to make influential discoveries that result in high-impact publications and contribute to the overall goal of developing new medicines to treat drug-resistant bacterial infections.


Key Attributes:

  • Creative individual, careful experimentalist, and passionate scientist.
  • Driven individual with demonstrated track record of proactively seeking resources/advice, as needed, to advance research.
  • Strong ability to identify most efficient path to advancing projects.


Essential Functions:

  • Independently pursue important scientific questions using multi-disciplinary skills and experimental techniques.
  • Attend and present data at scientific research conferences.
  • Interpret and clearly communicate findings to a multi-disciplinary team of research biologists and chemists.


Essential Experience:

  • Natural product total synthesis.
  • Demonstrated track record of innovation as evidenced by high-impact publications.
  • Willingness to learn new technical skills as required to address goals of research project.
  • Possesses exceptional ability to analyze and present applicable data.
  • Current US work authorization required.


Preferred Experience:

  • Familiarity with aminoglycoside or sugar chemistry.



  • Ph.D. in Synthetic Chemistry or related field (recent graduate within 18 months)

Preferred Additional Skills:

  • Exceptional written and verbal communication skills.
  • Excellent decision making and organization skills.
  • Committed to the values of integrity, accountability, transparency, scientific rigor and drive.
  • Ability to travel domestically and internationally.
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