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Scientist I/II, Cellular Pharmacology

Position Summary:

Develops innovative experimental strategies to investigate the trafficking, subcellular localization and pharmacological interactions of research compounds and biologics within mammalian cells in in vitro/ex vivo cell and tissue-based, and in vivo model systems.  Translates those strategies into experimental results that inform go/no-go decisions on advancing the research molecules in the pipeline.  Efficiently explores, establishes and maintains productive research collaborations as necessary to advance programs.  Accountable for the progress of vendors, collaborators and internal personnel to rapidly reach project goals.

 

Key Attributes:

  • Passionate commitment to the discovery of novel medicines to treat serious, life-threatening diseases.
  • Strong ability to communicate, motivate and leverage internal and external collaborators.
  • Intrepid scientist able to efficiently operate in challenging, boundary-pushing areas of study with minimal supervision.
  • Driven individual with demonstrated track record of proactively seeking resource/advice as needed to advance research.
  • Strong ability to identify the most efficient path to advancing/de-risking programs.
  • Committed to the values of integrity, accountability, transparency, scientific rigor and drive.

 

Essential Functions:

  • Develops robust in vivo and cell/tissue-based assays to support internal projects.
  • Deploys a breadth of techniques (i.e. tissue/primary cell isolation/culture, RNAi, -omic, microscopic) to understand pharmacological mechanism(s) underlying a research compound’s effects.
  • Interprets the structure-activity relationships of compounds’ pharmacological effects to inform new compound design.
  • Evaluates and selects new product technologies which can accelerate internal research.
  • Identifies, evaluates and ensures collaborators (academic and commercial) possess required scientific expertise and resources to advance collaborative research programs.
  • Develops project strategy and communicates to stakeholders.
  • Generates novel ideas for project initiation by synthesizing the scientific literature and engaging the research community at scientific meetings.

 

Essential Experience:

  • Hands-on experience in cell culture including extensive work with primary cell lines and/or ex-vivo tissue samples.
  • Demonstrated ability to design informative animal studies and oversee their execution.
  • Demonstrated track record of innovation through research programs or impactful publications.
  • Experience initiating and overseeing successful research collaborations.
  • Able to manage multi-disciplinary tasks.
  • Sustained demonstration of technical proficiency, scientific creativity, scientific writing, collaborations with others and independent thought.
  • Possesses exceptional ability to analyze and present applicable data.

 

Preferred Experience:

  • Experience with confocal microscopy and other advanced imaging techniques.
  • Experience studying the subcellular localization/trafficking of small molecules/proteins.
  • Extensive hands-on experience with animal handling/in vivo experiments.
  • Demonstrated ability to work in an interdisciplinary, fast-paced environment.
  • Experience mentoring junior scientists in the execution of complex experiments.
  • Success leading a multi-disciplinary team.
  • 4+ years of industry or post-doctoral work.

 

Education:

  • Requires a Ph.D. in cell biology, biochemistry, pharmacology or a related discipline.

 

Preferred Additional Skills:

  • Proven ability to positively impact company culture and demonstrate flexibility in fast paced environment.
  • Ability to travel domestically and internationally.
  • Committed to the values of integrity, accountability, transparency, scientific rigor and drive.
  • Current US work authorization required.
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